Responsibilities
- Provide expertise in process engineering, design, and on-going improvements for facility startup and manufacturing activities
- Support Single-Use (SU) program development and execution in collaboration with internal and external partners
- Author and/or review process descriptions, technical reports, and impact assessments/root cause investigations
- Support equipment commissioning, training, and validation activities
- Provide on-the-floor support to implement improvements for the process, equipment, or operational procedures including evaluation and testing of new technologies, new operating strategies, and equipment troubleshooting for GMP manufacturing
- Support recipe generation and updates for process equipment such as bioreactors, chromatography systems, and TFF systems
- Comply with GMPs, safety, and other policies
- Keep current with advances in technologies; evaluate and recommend new technologies that will be useful in expanding and enhancing platform processes; help coordinate deployment across the Audentes manufacturing network as appropriate
- Interact closely with vendors for SU materials and equipment procurement, as well as new technology implementation
- Support data management including the trending of process outcomes and in-process data to enhance process understanding and improvements
- Interact closely with multiple interdisciplinary groups (Manufacturing, Quality Assurance, Quality Control, Process Development, Facilities, Validation, Automation, etc.)
Required Qualifications
- BS or MS in Chemical/Mechanical/Biological Engineering or Life Sciences plus 5+ years of experience in life sciences, including 3+ years as a Processor Manufacturing Engineer
- Knowledge of equipment and systems used for upstream and/or downstream unit operations
- Capable of working independently at times, with minimal supervision, and managing multiple projects
- Sense of urgency and enthusiasm
- Demonstrated success and desire to work within a fast-paced environment under challenging timelines
- Strong attention to detail supported by excellent time management and organizational skills
- Proficiency with MS Office (Excel, PowerPoint, Word, Project, and Visio)
- Models our Core Values: Be Bold, Care Deeply, #GetStuffDone - is experienced as someone who exemplifies the culture we want to create; operates with transparency; is trusted
Preferred Qualification
- Experience with scale-up/scale-down and tech transfer
- Experience with single-use equipment and systems including understanding the effects of leachable ad extractable chemicals on process performance and product quality
- Working knowledge of cGMPs and good documentation practices (GDP)
- Experience in a design firm or consulting setting
- Experience with process and equipment design engineering such as hydraulic calculations, equipment sizing, process simulations, Heat and Material Balances (H&MB), Process Flow Diagrams (PFDs), Piping and Instrumentation Diagrams (P&IDs), and User Requirement Specification (URS) development
- Experience leading or supporting commissioning and qualification-related activities such as FAT, SAT, and IQ/OQ